Antibiotic resistance occurs when microorganisms such as bacteria no longer respond to antibiotics or drugs designed to kill them. Antibiotics are medicines vital to modern medicine. Their ability to kill microorganisms without harming the patients has saved millions of lives directly and made all medical procedures, from caesarean section to chemotherapy, much safer. But, today, after decades of overuse and misuse in human medicine as well as on animal farms, the situation has dramatically changed. The most relevant human pathogens have acquired resistance to virtually any new antibiotic that was put on market for human use. In addition, COVID-19 pandemic also greatly impacted antibiotic use and available data show an alarming increase in resistant infections. In addition, topical and oral antibiotics are often ineffective even in treatment of susceptible infections because they are unable to attack the biofilm but at the same time application of antibiotics inherently disrupt native, protective bacteria. So, it is clear that there ia an urgent need for development of non-conventional strategies to prevent and treat infections in new inovative ways.